Glioblastoma

Diagnosis

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• signs of intracranial pressure, neurological failuires or epileptical seizuires

• symptoms: e.g. headache, dizziness, emesis, vision impairment

• very short anamnesis of weeks or a few months

• diagnosis using MRI scan, CT scan, biopsy

• irregularly, highly receptive contrast agent

• central decreased contrast enhancing (hypodense center)

• diffuse infiltration of surrounding brain tissue

• tendency to high-volume central necoris and peritumorous edema

• main location: cerebral hemisppheres and corpus callosum("butterfly glioma")

• surrounded by an expanded white matter edema

• at diagnosis often bigger than 2 cm

• misdiagnosis: e.g. stroke
  
  

Treatment

• Surgery
• Radiation therapy on tumor volume and safety margin of 2 cm
• Chemotherapy
• Clinical study
  
  

Treatment for recurrent GBM

• Surgery
• Radiation therapy
• Chemotherapy
• Clinical study
  
  

Developing

• relativly fast groth
• recurrence even after successful surgery / therapy usually within one year

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