Glioblastoma

The glioblastoma (GBM) is a primary brain tumour that emerges from the glia cells. According to the WHO classification, this aggressive brain tumour is classified as WHO-grade IV.

   

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Histology of Glioblastoma

  • features necrosis and hemorrhage
  • high poliferation and fast growth
  • very malignant

 

Epidemology of Glioblastoma

  • average age between 45 and 60, but also younger patients can be affected
  • twice as often in men

 

Symptoms of Glioblastoma

  • signs of intracranial pressure, neurological failures or epileptical seizures
  • headache
  • dizziness
  • emesis
  • vision impairment

 

Diagnosing Glioblastoma

  • very short anamnesis of weeks or a few months
  • diagnosis using MRI scan, CT scan, biopsy
  • irregularly, highly receptive contrast agent
  • central decreased contrast enhancing (hypodense center)
  • diffuse infiltration of surrounding brain tissue
  • tendency to high-volume central necoris and peritumorous edema
  • main location: cerebral hemisppheres and corpus callosum ("butterfly glioma")
  • surrounded by an expanded white matter edema
  • at diagnosis often bigger than 2 cm
  • misdiagnosis: e.g. stroke

 

Therapy of Glioblastoma

  • surgerey
  • radioherapy on tumour volume and safety margin of 2 cm
  • chemotherapy
  • clinical trial

 

Therapy of Recurrent Glioblastoma

  • renewed surgery
  • second radiotherapy
  • chemotherapy
  • clinical trial

 

Course of Glioblastoma

  • relatively fast growth with infiltration of surrounding tissue
  • recurrence even after successful surgery / therapy usually within one year

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