Craniopharyngioma

Craniopharyngioma are benign tumours that arise from a malformation of remaining tissue in the area of the pituitary gland. The malformation already develops embryonic, whereby causes are not known yet.

Histology of Craniopharyngeoma

  • adamantinomatous craniopharyngioma (90% of all craniopharyngioma)
  • papillary craniopharyngioma

 

Epidemiologye of Craniopharyngeoma

        • first peak age between 5 and 10
        • second peak age between 50 and 75

               

              Symptoms of Craniopharyngeoma

                    • partial or total hypopituitarism (e.g. avolition and fatigue)
                    • signs of intracranial pressure (headache, emesis, vomiting)
                    • disturbed vision and restriction of visual field
                    • developmental delays
                    • deterioration in performance

                           

                          Diagnosing Craniopharyngeoma

                              • CT or MRI with contrast agent
                              • endocrinological examination


                                    Therapy of Craniopharyngeoma

                                        • no standard therapy
                                        • often surgical removal
                                        • possibly irradiation of residual tumour
                                        • only biopsy in connection with radiotherapy haven´t gained acceptance

                                             

                                            Therapy of Recurrent Craniopharyngeoma

                                                  • if possible (re-)operation
                                                  • (second) irradiation

                                                         

                                                        Aftercare of Craniopharyngeoma

                                                              • in first year every six months
                                                              • once a year if findings are inconspicuous
                                                              • regular hormon examinations

                                                                     

                                                                    Course of Craniopharyngeoma

                                                                      • high propensity for recurrence if tumour has infiltrated surrounding tissue
                                                                      • even after subsequent irradiation new relapses without any treatment options can occur

                                                                         

                                                                        Prognosis of Craniopharyngeoma

                                                                              • depending on extent of surgery
                                                                              • small tumours that can be removed transnasally have a good prognosis

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