Ganglioglioma are primary brain tumours that emerge from glia- and neuroplastic ganglion cells. According to WHO classification it is mostly classified as WHO grade I.

Histology of Ganglioglioma

  • mainly slowly growing tumour WHO grade I
  • also WHO grad II and III can occur
  • emerge from neoplastic ganglion cells (neural cells) and glia cells (provide support and protection of neurons)

Epidemiology of Ganglioglioma

  • especially in children and young adults
  • represent less than 2% of all primary brain tumours

Symptoms of Ganglioglioma

  • epileptic seizures
  • signs of intracranial pressure (headache, nausea, emesis)
  • symptoms related to localisation

Diagnosing Ganglioglioma

  • irregular and slight enhancement of contrast agent in MRI
  • clearly defined lesion
  • usually feature cysts
  • in 35-50% of the cases calcifications
  • can basically occur in the entire CNS
  • main localisation in frontal lobe

Therapy of Ganglioglioma

  • surgery (if possible complete resection of the tumour)
  • in anaplastic tumours (WHO grade III) postoperative treatment with radiotherapy and/or chemotherapy

Course of Ganglioglioma

  • astrocytic parts rarely transform to WHO grade III or glioblastoma

Prognosis of Ganglioglioma

  • favorable prognosis
  • after complete surgical removal normal life expectancy can frequently be reached

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