Glioblastoma
The glioblastoma (GBM) is a primary brain tumour that emerges from the glia cells. According to the WHO classification, this aggressive brain tumour is classified as WHO-grade IV.
Please note that the following threads of our forum are currently only available in German language.
Aktuelles aus dem Glioblastom Forum
Aktuelle Beiträge zum Thema Glioblastom | Antw. |
|---|---|
| 2 Operationen innerhalb von 8 Wochen | 1 |
| Therapie nach Ende des Stupp Protokolls | 3 |
| Tumor breitet sich über die Hirnhäute aus | 7 |
| Methadoneinnahme: Wie lange Temozolomid einnehmen? | 3 |
| Nebenwirkungen Kombi-Therapie CCNU+Temozolomid | 7 |
Histology of Glioblastoma
- features necrosis and hemorrhage
- high poliferation and fast growth
- very malignant
Epidemology of Glioblastoma
- average age between 45 and 60, but also younger patients can be affected
- twice as often in men
Symptoms of Glioblastoma
- signs of intracranial pressure, neurological failures or epileptical seizures
- headache
- dizziness
- emesis
- vision impairment
Diagnosing Glioblastoma
- very short anamnesis of weeks or a few months
- diagnosis using MRI scan, CT scan, biopsy
- irregularly, highly receptive contrast agent
- central decreased contrast enhancing (hypodense center)
- diffuse infiltration of surrounding brain tissue
- tendency to high-volume central necoris and peritumorous edema
- main location: cerebral hemisppheres and corpus callosum ("butterfly glioma")
- surrounded by an expanded white matter edema
- at diagnosis often bigger than 2 cm
- misdiagnosis: e.g. stroke
Therapy of Glioblastoma
- surgerey
- radioherapy on tumour volume and safety margin of 2 cm
- chemotherapy
- clinical trial
Therapy of Recurrent Glioblastoma
- renewed surgery
- second radiotherapy
- chemotherapy
- clinical trial
Course of Glioblastoma
- relatively fast growth with infiltration of surrounding tissue
- recurrence even after successful surgery / therapy usually within one year
