Glioblastoma

Aktuelles aus dem Glioblastom Forum

Histology of Glioblastoma

• features necrosis and hemorrhage
• high poliferation and fast growth
• very malignant

Epidemology of Glioblastoma

• average age between 45 and 60, but also younger patients can be affected
• twice as often in men

Symptoms of Glioblastoma

• signs of intracranial pressure, neurological failures or epileptical seizures
• headache
• dizziness
• emesis
• vision impairment

Diagnosing Glioblastoma

• very short anamnesis of weeks or a few months
• diagnosis using MRI scan, CT scan, biopsy
• irregularly, highly receptive contrast agent
• central decreased contrast enhancing (hypodense center)
• diffuse infiltration of surrounding brain tissue
• tendency to high-volume central necoris and peritumorous edema
• main location: cerebral hemisppheres and corpus callosum ("butterfly glioma")
• surrounded by an expanded white matter edema
• at diagnosis often bigger than 2 cm
• misdiagnosis: e.g. stroke

Therapy of Glioblastoma

• surgerey
• radioherapy on tumour volume and safety margin of 2 cm
• chemotherapy
• clinical trial

Therapy of Recurrent Glioblastoma

• renewed surgery
• second radiotherapy
• chemotherapy
• clinical trial

Course of Glioblastoma

• relatively fast growth with infiltration of surrounding tissue
• recurrence even after successful surgery / therapy usually within one year

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