Pontine Glioma

Pontine glioma are tumours that arise in the lower part of the brain stem (pons). They usually occur in children, but can also be observed in adults.

Histology of Pontine Glioma

  • occur in or in the region of the pons (part of brain stem)
  • in children and adolescents often pilocytic astrocytoma (Who grade I)
  • in adults often diffuse (WHO grade II) or anaplastic (WHO grade III) astrocytoma
  • classified as WHO-grade IV because they are difficult to treat due to locaisation

     

    Epidemiology of Pontine Glioma

        • mainly occur in first decade of life
        • rarely occur in adulthood

             

            Symptoms of Pontine Glioma

                  • signs of intracranial pressure (headache, emesis, vomiting)
                  • impaired balance
                  • hemiparesis

                         

                        Diagnosing Pontine Glioma

                          • with MRI and/or CT
                          • no biopsy necessary, imagings are very characteristic (localisation)
                          • distension of pons
                          • diffuse growth


                                Therapy of Pontine Glioma

                                  • due to localisation no surgery possible
                                  • participation in a clinical trial (usually radio- and chemotherapy)

                                     

                                    Therapy of Recurrent Pontine Glioma

                                        • participation in a clinical trial

                                             

                                            Course of Pontine Glioma

                                              • high tendency to recurrence

                                                 

                                                Prognosis of Pontine Glioma

                                                      • poor prognosis
                                                      • prognosis is tried to improve prognosis with therapy-optimising studies and preospective studies

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